Generic Estrace is used for treating conditions due to menopause (eg, hot flashes; vaginal itching, burning, or dryness), treating vulval or vaginal atrophy, and preventing osteoporosis (brittle bones). It is also used for estrogen replacement therapy after failure of the ovaries and to relieve the symptoms of breast cancer.
Generic Tofranil is used for treating depression. It is also used in some children to help reduce bedwetting. It works by increasing the activity of certain chemicals in the brain that help elevate mood.